It's back! Amazon's $139 refurbished Kindle Fire deal returns for one more day

Did you miss late March's $139 Amazon Gold Box Deal on the refurbed Kindle Fire? Well, the retailer is giving you another chance, bringing back the deal for today (May 5th). It's the same discount as the last go-around -- namely, $30 off the standard price for the refurbished Fire -- and Amazon still certifies and reseals it. It's even throwing in a one-year warranty for good measure. Also like last time around, there's a limit of five discounted Fires per customer, so don't get too grabby.

It's back! Amazon's $139 refurbished Kindle Fire deal returns for one more day originally appeared on Engadget on Wed, 02 May 2012 13:29:00 EDT. Please see our terms for use of feeds.

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Test to 'predict breast cancer'

1 May 2012 Last updated at 03:54 ET By Michelle Roberts Health editor, BBC News website

Dr James Flanagan, who led the research, says a pre-test for breast cancer could save lives

A genetic test could help predict breast cancer many years before the disease is diagnosed, experts hope.

Ultimately the findings, in the journal Cancer Research, could lead to a simple blood test to screen women, they say.

The test looks for how genes are altered by environmental factors like alcohol and hormones - a process known as epigenetics.

One in five women is thought to have such a genetic "switch" that doubles breast cancer risk.

Continue reading the main story

?Start Quote

By piecing together how this happens, we can look at ways of preventing the disease and detecting it earlier to give people the best possible chance of survival?

End Quote Baroness Delyth Morgan Breast Cancer Campaign

The scientists from Imperial College London analysed blood samples from 1,380 women of various ages, 640 of whom went on to develop breast cancer.

And they found a strong link between breast cancer risk and molecular modification of a single gene called ATM, which is found on white blood cells.

Predicting cancer

They then looked for evidence of what was causing this change. Specifically, they looked for a chemical effect called methylation, which is known to act as a "gene switch".

Women showing the highest methylation levels affecting the ATM gene were twice as likely to develop breast cancer compared with those with the lowest levels.

In some cases the changes were evident up to 11 years before a breast tumour was diagnosed.

Dr James Flanagan, of Imperial College London, who led the new research, said: "We know that genetic variation contributes to a person's risk of disease.

"With this new study we can now also say that epigenetic variation, or differences in how genes are modified, also has a role.

"We hope that this research is just the beginning of our understanding about the epigenetic component of breast cancer risk and in the coming years we hope to find many more examples of genes that contribute to a person's risk.

"The challenge will be how to incorporate all of this new information into the computer models that are currently used for individual risk prediction."

It is not yet clear why breast cancer risk might be linked to changes in a white blood cell gene.

Continue reading the main story

Epigenetics

• The focus is on targeting cancer-causing errors in the way the body reads DNA code, rather than errors in the genetic code itself
• A series of chemical switches determine whether genes are turned on or off, and ultimately what the cell will look like and how it will function
• Alterations in this "epigenetic" control can lead to cancer
• Environmental factors like hormones can act as triggers for these errors
• Scientists are working on new drugs that can regulate gene expression and effectively solve epigenetic problems

But the team envisage that a blood test could be used in combination with other information about breast cancer risk, such as family history and the presence of other known breast cancer genes, to help identify those women at greatest risk of developing the disease in the future.

These women could then be closely monitored and offered pre-emptive treatment, such as surgery.

Baroness Delyth Morgan of the Breast Cancer Campaign, which funded the work, said: "By piecing together how this happens, we can look at ways of preventing the disease and detecting it earlier to give people the best possible chance of survival."

Laura Bell of Cancer Research UK said: "This study gives us a fascinating glimpse of the future and the promise that the emerging field of epigenetics holds. But it's too early to say exactly how these particular changes might affect our ability to detect who is likely to develop certain types of cancer.

"With further studies, scientists will increase our knowledge of how genetic switches like this interplay together to affect breast cancer risk, with the hope that one day this could lead to a blood test that could help predict a woman's chance of getting the disease."

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Ariana Grande: Dating Josh Hutcherson!

Josh Hutcherson is no longer hungering for a girlfriend. Why? Because he's reportedly playing the game of love with Ariana Grande!

An insider tells Life & Style that the actor is romantically involved with Victorious star Ariana Grande. She plays Cat Valentine on that Nickelodeon sitcom.

"They've been seeing each other since the beginning of the year," a source tells the tabloid, adding that Grande even attended the Los Angeles premiere of The Hunger Games with her man, but didn't walk down the red carpet because "they've been trying to keep it low-profile."

Hutcherson previously dated Vanessa Hudgens.

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Vungle Hustles Its Way Into $2M All-Star Seed Round For Mobile App Video Trailers Network

Vungle, a new company that wants to help mobile developers market their apps through video "trailers," has just raised an enormous $2 million seed round from the who's who of Silicon Valley. The round includes Google Ventures, AOL Ventures [Disclosure: TechCrunch is owned by AOL], Crosslink Capital, as well as several notable angels like SV Angel's Ron Conway, 500 Startups' Dave McClure, SoftTech VC's Charles Hudson, Maynard Webb, Scott McNealy and Tim Draper.

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A Short History of Mitt Romney's Views on the Detroit Bailout (Atlantic Politics Channel)

Share With Friends: | | Politics - Top Stories Stories, RSS and RSS Feed via Feedzilla.

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Tree cricket song has note of variability

Wing segments form chorus that helps shape insect?s sounds

Web edition : Monday, April 30th, 2012

Unique wings allow one type of male tree cricket to hum a different sort of tune ? one that encompasses a wide range of pitches. The discovery could mean that these males are saying a lot more than previously thought, and that potential mates might be listening for these notes.

?The frequencies might be carrying some information about the condition of the male.? An insect that is able to sing faster, and hence at a higher frequency, might actually be quite well fed, or he?s in a nice warm place you might want to be in,? says Natasha Mhatre of the University of Bristol in England. ?You now have to ask: ?What kind of information is that frequency carrying???

Crickets produce sound by rubbing their wings together. For most crickets ? including field and bush crickets ? males can produce only one musical note. Generally, the pitch of the male?s song is directly related to his size. Researchers believe that when females scout for a potential mate, they tend to be drawn to songs of deeper frequency or pitch, which are produced by larger crickets.

But certain tree crickets were known to vary their tune. Scientists had observed, for instance, that a species from southern India called Oecanthus henryi produces high-pitch sounds at warmer temperatures. Until now, it wasn?t fully understood how these critters could do this.

In the new work, scientists found that five individual segments making up a large part of this tree cricket?s wing vibrate to produce sound. That differs from most other crickets, in which only one small section of the wing is involved.

The tree cricket?s particularly long wings accommodate different types of bending ? which is associated with different frequencies. These insects can make sounds than range between 2.3 and 3.7 kHz. Using computer simulations, researchers found that smaller wings could not produce such different pitches.

Also, at higher temperatures, these crickets tended to move their wings faster to produce higher-frequency sounds, Mhatre and her colleagues report online April 30 in the Proceedings of the National Academy of Sciences.

Because the pitch of the male?s song is not tied to body size in this species, the findings raise questions about exactly what information females are gleaning when they hear these songs, says Rex Cocroft, an entomologist at the University of Missouri in Columbia.

?It?s going to change the dynamics of mate choice,? Cocroft says.

Ann Hedrick, a behavioral ecologist at the University of California, Davis, wonders what these multiple notes could mean for the Oecanthus females.

?With these tree crickets changing their frequency all over the place, it means that their females must be able to hear and respond to a broad series of frequencies,? says Hedrick. ?Also, if there are further evolutionary steps in the male song, the question is: Will the females go along with them??

Found in: Life

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Peter Jackson responds to "Hobbit" preview fallout

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