Limbaugh Is Right to See Demographic Change as a Threat

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ITU meets to define 4K and 8K UHDTV parameters

This month NHK has been previewing a slew of Super Hi-Vision equipment, but there's still much work to be done to make high res broadcasts a reality worldwide. There's where the ITU steps in, and as it did for HDTV back in the 90s it's been meeting to decide just what 4K and 8K Ultra High Definition TV (UHDTV) broadcasts are and how they will work. There's no word on minimum pixel counts for the standards -- we expect that quad-HD vs. 4K battle to rage on, remember these are the people who "defined" 4G -- but they're establishing color range, frame rate, and whether the broadcasts will go over unused satellite bandwidth or regular antenna frequencies. If you're somehow confused by the 33MP video streams that are coming our way... some day, check out a video featuring European Broadcast Union Deputy Director of Technology and Development David Wood.

Continue reading ITU meets to define 4K and 8K UHDTV parameters

ITU meets to define 4K and 8K UHDTV parameters originally appeared on Engadget on Thu, 24 May 2012 08:26:00 EDT. Please see our terms for use of feeds.

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Stem-cell-growing surface enables bone repair

ScienceDaily (May 23, 2012) ? University of Michigan researchers have proven that a special surface, free of biological contaminants, allows adult-derived stem cells to thrive and transform into multiple cell types. Their success brings stem cell therapies another step closer. To prove the cells' regenerative powers, bone cells grown on this surface were then transplanted into holes in the skulls of mice, producing four times as much new bone growth as in the mice without the extra bone cells.

An embryo's cells really can be anything they want to be when they grow up: organs, nerves, skin, bone, any type of human cell. Adult-derived "induced" stem cells can do this and better. Because the source cells can come from the patient, they are perfectly compatible for medical treatments.

In order to make them, Paul Krebsbach, a professor of biological and materials sciences in the School of Dentistry, said, "We turn back the clock, in a way. We're taking a specialized adult cell and genetically reprogramming it, so it behaves like a more primitive cell."

Specifically, they turn human skin cells into stem cells. Less than five years after the discovery of this method, researchers still don't know precisely how it works, but the process involves adding proteins that can turn genes on and off to the adult cells.

Before stem cells can be used to make repairs in the body, they must be grown and directed into becoming the desired cell type. Researchers typically use surfaces of animal cells and proteins for stem cell habitats, but these gels are expensive to make, and batches vary depending on the individual animal.

"You don't really know what's in there," said Joerg Lahann, an associate professor of chemical engineering and biomedical engineering. For example, he said that human cells are often grown over mouse cells, but they can go a little native, beginning to produce some mouse proteins that may invite an attack by a patient's immune system.

The polymer gel created by Lahann and his colleagues in 2010 avoids these problems because researchers are able to control all of the gel's ingredients and how they combine. "It's basically the ease of a plastic dish," said Lahann. "There is no biological contamination that could potentially influence your human stem cells."

Lahann and colleagues had shown that these surfaces could grow embryonic stem cells. Now, Lahann has teamed up with Krebsbach's team to show that the polymer surface can also support the growth of the more medically-promising induced stem cells, keeping them in their high-potential state. To prove that the cells could transform into different types, the team turned them into fat, cartilage, and bone cells.

They then tested whether these cells could help the body to make repairs. Specifically, they attempted to repair 5-millimeter holes in the skulls of mice. The weak immune systems of the mice didn't attack the human bone cells, allowing the cells to help fill in the hole.

After eight weeks, the mice that had received the bone cells had 4.2 times as much new bone, as well as the beginnings of marrow cavities. The team could prove that the extra bone growth came from the added cells because it was human bone.

"The concept is not specific to bone," said Krebsbach. "If we truly develop ways to grow these cells without mouse or animal products, eventually other scientists around the world could generate their tissue of interest."

In the future, Lahann's team wants to explore using their gel to grow stem cells and specialized cells in different physical shapes, such as a bone-like structure or a nerve-like microfiber.

The paper reporting this work is titled "Derivation of Mesenchymal Stem Cells from Human Induced Pluripotent Stem Cells Cultured on Synthetic Substrates" and it appears online as an article accepted to the journal Stem Cells, to be published in a future issue. The study was funded by the National Institutes of Health. The university is pursuing patent protection for the intellectual property, and is seeking commercialization partners to help bring the technology to market.

Paul Krebsbach is also the Roy H. Roberts Professor of Dentistry and a professor of biomedical engineering. Joerg Lahann is also an associate professor of materials sciences and engineering, an associate professor of macromolecular sciences and engineering, and the director of the Biointerfaces Institute.

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The above story is reprinted from materials provided by University of Michigan.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. L.G. Villa-Diaz, S.E. Brown, Y. Liu, A.M. Ross, J. Lahann, J.M. Parent, P.H. Krebsbach. Derivation of Mesenchymal Stem Cells from Human Induced Pluripotent Stem Cells Cultured on Synthetic Substrates. Stem Cells, 2012; 30 (6): 1174 DOI: 10.1002/stem.1084

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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Romney Talks (TIME)

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The Data Center Journal OnRamp's Data Center Disaster Recovery ...

Austin-based Data Center operations company, OnRamp Access, is helping businesses in hurricane-prone regions protect their IT infrastructure with disaster recovery solutions designed to keep online operations up and running in the event of a natural disaster. This year, meteorologists have predicted that storms forming within the Atlantic Basin region, including the Gulf of Mexico, will have a higher likelihood of occurring closer to the United States than in years past. This forecast poses an imminent threat to businesses lining the coast, with the potential for prevailing winds to push the forces of these storms directly inland, and placing businesses in the path of possible destruction. OnRamp assists companies around the country in maintaining reliable disaster recovery operations deployed from its Austin Data Center with the critical infrastructure and Full7Layer Support necessary for 100% uptime 24/7/365.

According to the U.S. Department of Labor ? Bureau of Labor Statistics, ?40% of all businesses that experience a disaster never reopen. Of the remaining businesses, 25% close within the following year.? OnRamp?s disaster recovery solutions provide companies who cannot afford downtime, loss of productivity and revenue with a secure, redundant and reliable environment to deploy their operations for business continuity. OnRamp?s team of experienced network engineers and technical staff are available around the clock to offer companies more than just a place to store data safe from harm. The Austin Data Center provides Full7Layer Support from onsite engineers with experience all the way through the application layer, thus removing the need for companies to travel between their office and their data center to diagnose, troubleshoot, or remedy problems inside their rack. Because OnRamp can support customers above the hardware layer, companies often view OnRamp as an extension of their IT department, especially in times of unforeseen disasters.

?When disasters strike, it is essential for businesses to establish effective IT partners in remote locations, to ensure the confidentiality, availability, and integrity of data operations,? stated OnRamp?s Founder, Chad Kissinger. ?In addition to being a safe and secure environment for disaster recovery, companies are more likely to be successful partnering with OnRamp because we provide a level of support that far exceeds that of our competitors. Our experienced, on-site support staff can facilitate the installation, monitoring and maintenance of equipment, which is important to disaster recovery customers whose IT staff is far removed from their equipment by design.?

OnRamp has helped hundreds of businesses across the country, and on the coast, successfully replicate their online infrastructure at the company?s Austin Data Center in response to past natural disasters, including Hurricanes Rita and Ike. Austin is one of the safest areas in the country for storing data. Situated away from floodplains, landslides, seismic faults, and having no reported incidence of hurricanes, Austin provides a geographically stable environment for disaster recovery. Not only is Austin free from major weather related threats, its physical location within the US is an added benefit in terms of latency and general connectivity, making it perfect for the placement of infrastructure that is intended to serve data to end users all over the US.

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Aussie boat race activist banned from diamond jubilee events

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Japan's debt rating downgraded by Fitch

By msnbc.com staff and news wires

Fitch lowered its ratings on Japan's sovereign debt Monday, citing?its "leisurely" approach to fixing its fiscal woes.

Fitch said it lowered Japan's long-term foreign and local currency issuer default ratings (IDRs) to 'A+' from 'AA' and 'AA-' respectively with a negative outlook.

"The downgrades and Negative Outlooks reflect growing risks for Japan's sovereign credit profile as a result of high and rising public debt ratios," said Andrew Colquhoun, Head of Asia-Pacific Sovereigns at Fitch, in a statement. "The country's fiscal consolidation plan looks leisurely relative even to other fiscally-challenged high-income countries, and implementation is subject to political risk."

Reuters said the downgrade could serve as a chilling reminder to highly indebted countries in Europe that urgent action is needed to trim public debt and prevent concerns about sovereign debt from weighing further on the global economy.

Several euro zone countries have been hit with multiple downgrades as the region struggles to deal with its mounting debt crisis.

The United States is expected to reach a $16.4 trillion government debt ceiling after November presidential elections, laying the ground for another protracted political battle over how to cut the budget, similar to a bitter debate that rattled financial markets last year.

Reuters contributed to this report.

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